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Latanoprost

Brand Name: Xalatan
Drug Class: Antiglaucoma agent
Available in: Ophthalmic solution
Available Without a Prescription? No
Available as a Generic? No

Side Effects

Serious: Chest pain, difficulty breathing. Call your doctor right away.

Common: Blurred vision, burning and stinging of the eye, sensation of something in the eye, increased brown pigmentation of the iris, eye redness.

Less Common: Dry eye, excessive tearing, eye pain, lid crusting, swollen eyelid, eyelid pain or discomfort, sensitivity to light, upper respiratory tract infection, double vision, pain in the chest and back.

Principal Uses

To treat glaucoma.

How the Drug Works

Glaucoma, a sight-threatening disorder, occurs when the aqueous humor (fluid inside the eye) cannot drain properly, causing increased pressure within the eyeball (intraocular pressure). Increased eye pressure can damage the optic nerve and lead to a gradually progressive loss of vision. Latanoprost promotes outflow of aqueous humor, thereby reducing intraocular pressure.

Dosage

1 drop of latanoprost in each eye once daily in the evening.

Onset of Effect

3 to 4 hours.

Duration of Action

24 hours or more.

Dietary Advice

This medication can be used without regard to diet.

Storage

Store in a tightly sealed container away from heat, moisture, and direct light. Do not allow the medicine to freeze.

If You Miss a Dose

Apply it as soon as you remember. If it is near the time for the next dose, skip the missed dose and resume your regular dosage schedule. Do not double the next dose.

Stopping the Drug

The decision to stop using the drug should be made by your doctor.

Prolonged Use

See your doctor regularly for tests and examinations if you must take this drug for a prolonged period.

Precautions

Over 60: No special problems are expected.

Driving and Hazardous Work: Do not drive or engage in hazardous work until you determine how the medicine affects your vision.

Alcohol: No special precautions are necessary.

Pregnancy: Latanoprost has not caused birth defects in animals. Human studies have not been done. Before you take latanoprost, tell your doctor if you are pregnant or plan to become pregnant.

Breast Feeding: Latanoprost may pass into breast milk; caution is advised. Consult your doctor for advice.

Infants and Children: The safety and effectiveness of latanoprost in infants and children have not been established.

Special Concerns: To use the eye drops, first wash your hands. Tilt your head back. Gently apply pressure to the inside corner of the eyelid and with the index finger of the same hand, pull downward on the lower eyelid to make a space. Drop the medicine into this space and close your eye. Apply pressure for 1 or 2 minutes while keeping the eye closed without blinking. Then wash your hands again. Make sure the tip of the dropper does not touch your eye, finger, or any other surface. Latanoprost may make your eyes more sensitive to sunlight. If this occurs, wear sunglasses or avoid exposure to bright light as necessary. Latanoprost may change eye color, increasing the brown pigment in the iris over a period of months or years. The color change may be permanent. Latanoprost contains ingredients that may damage contact lenses. Contact lenses should be removed 15 minutes before applying the medication and reinserted 15 minutes or more afterward.

Overdose

Symptoms: No specific ones have been reported.

What to Do: An overdose of latanoprost is unlikely to be life-threatening. If a large volume enters the eyes, flush with water. If someone accidentally ingests the medicine, call your doctor, emergency medical services (EMS), or the nearest poison control center.

Drug Interactions

Other drugs may interact with latanoprost. Consult your doctor for specific advice if you are taking any other prescription or over-the-counter medication. If you are using other ophthalmic medications to reduce fluid pressure in the eye, administer them at least 5 minutes apart.

Food Interactions

No known food interactions.

Disease Interactions

Use of latanoprost may cause complications in patients with liver or kidney disease, since these organs work together to remove the drug from the body.

 

From The Johns Hopkins Consumer Guide to Drugs. You can order this book now on our secure server.

 

 

 

 


 


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2005
WHITE PAPERS
Vision

The vision White Paper from The Johns Hopkins White Papers series is an annual, in-depth report written by Hopkins physicians.


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Johns Hopkins Consumer Guide to Drugs

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