Brand Name: Meridia
Drug Class: Inhibitor of neurotransmitter reuptake
Available in: Capsules
Available Without a Prescription? No
Available As a Generic? No
Serious: No serious side effects have yet been reported.
However, if you experience symptoms such as shortness of breath
pain that were not present before taking the medication, call
Common: Dry mouth, constipation, insomnia.
Less common: Headache,
increased sweating, increased blood pressure and
To aid in the medical management of obesity in
conjunction with a carefully supervised diet and exercise program.
only recommended for overweight people with a body mass index
(BMI) greater than 30 or greater than 27 in people with other
risk factors such as diabetes or high blood pressure.
Sibutramine affects the appetite control center in
the brain by inhibiting the reuptake of neurotransmitters like
The resulting increase in their availability suppresses appetite.
To start, 10 mg once a day. Dose may be increased up to
15 mg once a day.
Onset of Effect
Significant weight changes may take several weeks
or months to develop.
Duration of Action
When taking sibutramine regularly, most people
lose weight within the first six months. Weight loss is maintained
for the duration
Can be taken with a meal or on an empty stomach.
Store in a tightly sealed container away from heat, moisture,
and direct light.
If You Miss a Dose
If you miss a dose one day, do not double
the dose the next day. Resume your regular dosage schedule.
The decision to stop taking the drug should be made in
consultation with your physician.
The safety and effectiveness of sibutramine have
not been determined beyond 2 years of use.
Over 60: No specific studies have been done on older
Driving and Hazardous Work: Do not drive or engage
in hazardous work until you determine how the medicine affects
Alcohol: Sibutramine may increase the sedative effects
of alcohol. Consult you doctor for specific advice.
Pregnancy: Sibutramine should not be used by pregnant women. Before
taking sibutramine, tell your doctor if you are
pregnant or plan to become pregnant.
Breast Feeding: Sibutramine
should not be used by nursing mothers.
Infants and Children: Children under the age of 16 should not use sibutramine.
Special Concerns: Although no
serious adverse reactions have been reported with sibutramine
the time of
publication), other diet drugs have been associated
with an increased
of potentially grave cardiovascular and cardiopulmonary
problems. If you experience any unusual or disturbing
stop taking sibutramine and call your physician immediately.
Symptoms: No cases of overdose have been reported.
Do: If someone takes a much larger dose than prescribed or
a child swallows the drug, call your doctor, emergency medical
services (EMS), or the nearest poison control center immediately.
You should not take sibutramine if you take MAO
inhibitors, other weight loss medications, medications for depression,
medications, dihydroergotamine, meperidine, fentanyl, pentazocine,
dextromethorphan (found in many cough medicines), lithium, or
tryptophan. Sibutramine may interact with ketoconazole, erythromycin,
over-the-counter cough and cold medications, allergy medicines,
and decongestants. Consult your doctor for specific advice.
No known food interactions.
You should not take sibutramine if you have
coronary artery disease, angina, cardiac arrhythmia, history
of heart attack, congestive
heart failure, history of stroke, anorexia nervosa, history of
seizures, or narrow angle glaucoma. Sibutramine can substantially
raise blood pressure in some patients. Use of sibutramine may
cause complications in patients with liver or kidney disease,
since these organs work together to remove the medication from
the body. Consult your doctor if you have a history of migraines,
mental depression, Parkinson’s disease, thyroid disorders,
osteoporosis, gallbladder disease, a major eating disorder (anorexia
nervosa or bulimia nervosa), or any other medical problem.
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