Brand Names: Diurigen,
Drug Class: Thiazide
Available in: Tablets,
oral suspension, injection
Available Without a Prescription? No
Available as a Generic? Yes
Serious: Skin rash,
hives, intense itching, swelling of the mouth and throat, breathing
difficulty, serious heartbeat irregularities or palpitations, lightheadedness
or dizziness, unusual bleeding or bruising. Call your doctor immediately
if you experience any of these side effects.
depletion may lead to heart palpitations and weakness. Fluid
depletion may lead to dizziness, especially upon rising from
a sitting or lying position.
Less Common: Decreased
sexual ability, increased sensitivity to sunlight, loss of
appetite, gout, increased blood sugar (a problem for people
To treat high blood pressure and conditions causing
edema (swelling of body tissues as a result of excess salt and
How the Drug Works
Diuretics increase the excretion of salt and water
in the urine. By reducing the overall fluid volume in the body,
these drugs reduce blood volume and so reduce pressure within
the blood vessels.
Adults For high blood pressure: 250 mg once
a day. To reduce edema: 250 to 500 mg once a day or 2 or 3 days
Onset of Effect
2 hours after oral dose; 15 minutes after injection.
Duration of Action
6 to 12 hours.
Tablets should be taken with food.
Store in a tightly sealed container away from heat
and direct light. Keep the liquid form from freezing.
If You Miss a Dose
Take it as soon as you remember. If it is near
the time for the next dose, skip the missed dose and resume your
regular dosage schedule. Do not double the next dose.
Stopping the Drug
The decision to stop taking the drug should be
made by your doctor.
See your doctor regularly for examinations and
tests if you must take this medicine for an extended period.
Over 60: No special
problems are expected.
Driving and Hazardous Work: No
special precautions are necessary.
Alcohol: No special
precautions are necessary.
has caused birth defects in animals. Human studies have not been
done. This medicine should not be taken during pregnancy unless
recommended by your doctor. Other diuretics are preferred in
Breast Feeding: Chlorothiazide passes into breast milk; avoid or discontinue
use during the first month of nursing.
Infants and Children: This
drug generally is not prescribed for children.
Special Concerns: Chlorothiazide
is usually taken once a day. To prevent it from interfering
with sleep, take it in the morning (unless otherwise prescribed
your doctor). If you are taking it for high blood pressure,
follow the diet and weight control measures recommended by
Avoid exposure to sunlight, use a sunblock, or wear protective
clothing. This medicine may cause your body to lose potassium.
Follow your doctors instructions about eating potassium-rich
foods or taking a potassium supplement.
dizziness, drowsiness, muscle weakness, cramps, heartbeat irregularities,
What to Do: Call your
doctor, emergency medical services (EMS), or the nearest poison
control center immediately.
Consult your doctor for specific advice if you
are taking anticoagulants, cholestyramine, colestipol, drugs
for diabetes, nonsteroidal anti-inflammatory drugs, digitalis
drugs, or lithium.
No known food interactions.
Caution is advised when taking chlorothiazide.
Consult your doctor if you have any of the following: diabetes,
gout, lupus erythematosus, pancreatitis, heart disease, blood
vessel disease, liver disease, or kidney disease.
From The Johns
Hopkins Consumer Guide to Drugs. You can order
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