Names: Prevacid, Prevpac
Drug Class: Antacid/proton
Available in: Delayed-release
Available OTC? No
As Generic? No
Serious: No serious
side effects are associated with the use of this medication.
itching or rash, headache, dizziness.
Less Common: Abdominal
or stomach pain, nausea, increase or decrease in appetite,
anxiety, flu-like symptoms, constipation, coughing, mental
depression, muscle pain.
To treat stomach and duodenal (intestinal) ulcers,
gastroesophageal reflux disease (chronic heartburn caused by
the backwash of stomach acid into the esophagus), and conditions
that cause increased stomach acid secretion, such as Zollinger-Ellison
syndrome. To treat and prevent nonsteroidal anti-inflammatory
drug (NSAID)-associated stomach ulcers. Lansoprazole is also
prescribed in conjunction with the antibiotics amoxicillin and
clarithromycin to eradicate the bacterium H. pylori and thus
prevent the recurrence of duodenal ulcers caused by this bacterium.
How the Drug Works
Lansoprazole blocks the action of a specific enzyme
in the cells that line the stomach, thus decreasing the production
of stomach acid. Reduction of stomach acid creates a more favorable
environment for the eradication of H. pylori and promotes the
healing of ulcers.
Prevacid To treat duodenal ulcers:
Initial dose is 15 mg once a day; it may later be increased.
To treat gastroesophageal reflux disease: 15 mg once a day for
up to 8 weeks. To treat NSAID-associated stomach ulcers: 30 mg
once a day for 8 weeks. To reduce the risk of NSAID-associated
stomach ulcer: 15 mg once a day for up to 12 weeks. To treat
other conditions: Initial dose is 60 mg once a day; it may be
increased. Treatment usually runs 4 to 8 weeks. A second course
of treatment may be necessary. For Zollinger-Ellison syndrome:
Initial dose is 60 mg once a day; it may be increased. Prevpac To
prevent duodenal ulcers: 30 mg lansoprazole, 1 gram amoxicillin,
and 500 mg clarithromycin every 12 hours for 14 days.
Onset of Effect
1 to 3 hours.
Duration of Action
More than 24 hours.
The drug is best taken 30 minutes or more before
a meal, preferably breakfast.
Store in a tightly sealed container away from heat,
moisture, and direct light.
If You Miss a Dose
Take it as soon as you remember. However, if it
is near the time for the next dose, skip the missed dose and
resume your regular dosage schedule. Do not double the next dose.
Stopping the Drug
Take as prescribed for the full treatment period,
even if your symptoms improve before the scheduled end of therapy.
Lansoprazole should not be used indefinitely as
maintenance therapy for duodenal ulcer or esophagitis; other
treatments are advised.
Over 60: No special
problems are expected.
Driving and Hazardous Work: Avoid
such activities until you determine how the drug affects you.
Alcohol: Avoid alcohol
throughout the duration of therapy with this drug.
human studies have not been done. Before taking lansoprazole,
tell your doctor if you are pregnant or plan to become pregnant.
Breast Feeding: Lansoprazole
may pass into breast milk; consult your doctor for advice.
Infants and Children: Use
and dose for anyone under 18 should be determined by your doctor
Tell any doctor or dentist whom you see for treatment
that you are taking lansoprazole. Do not chew the capsules. If
you have trouble swallowing them, you may open them and sprinkle
the contents on one tablespoon of applesauce, cottage cheese,
yogurt, or similar food. If your doctor directs, you may take
an antacid along with lansoprazole.
Symptoms: No cases
of overdose have been reported.
What to Do: An overdose
is unlikely to be life-threatening. However, if someone takes
a much larger dose than prescribed, seek medical attention immediately.
Consult your doctor for specific advice if you
are taking ampicillin, sucralfate, iron salts or supplements,
cyclosporine, diazepam, disulfiram, ketoconazole, phenytoin,
No significant food interactions have been reported.
Caution is advised when taking lansoprazole. Consult
your doctor if you have liver disease, since it may increase
the risk of side effects.
From The Johns
Hopkins Consumer Guide to Drugs. You can order
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