Name: Deponit, Minitran,
Nitro-Bid, Nitro-Dur, Nitrocine, Nitrocine Timecaps, Nitrodisc,
Nitrogard, Nitroglyn, Nitrol, Nitrolingual, Nitrong, NitroQuick,
Nitrostat, Transderm-Nitro, Tridil
Drug Class: Nitrate
Available in: Capsules,
tablets, ointment, skin patch, aerosol
Available Without a Prescription? No
Available as a Generic? Yes
vision, severe or prolonged headache, skin rash, dry mouth.
Call your doctor immediately if you experience any of these
of face and neck, headache, nausea or vomiting, dizziness or
when getting up, rapid heartbeat, restlessness.
Less Common: Sore,
To prevent or relieve attacks of angina (chest
pain associated with heart disease).
How the Drug Works
Nitroglycerin relaxes the smooth muscle that
surrounds the blood vessels and increases the supply of blood
and oxygen to the heart. It also reduces the hearts
workload and demand for oxygen.
Ointment: 15 to 30 mg applied to skin
every 6 to 8 hours. Skin patch: 1 patch applied every
day, left on for 12 to 14 hours. Aerosol: 1 or 2 doses
on or under the tongue at 5-minute intervals to relieve angina
attack. Extended-release capsules: 2.5, 6.5, or 9 mg
every 12 hours; can be taken every 8 hours. Extended-release
tablets: 1.3, 2.6, or 6.5 mg every 12 hours; can be taken
every 8 hours. Sublingual (under tongue) or buccal (inside
the cheek) tablets: 0.15 to 0.6 mg repeated at 5-minute
intervals to treat angina attack.
If 3 tablets do not relieve pain, call your doctor.
Onset of Effect
Sublingual: 2 to 4 minutes. Buccal: 3
minutes. Oral: 20 to 45 minutes. Ointment and skin
patch: 30 minutes.
Duration of Action
Sublingual: 30 to 60 minutes. Buccal: 5
hours. Oral: 8 to 12 hours. Ointment: 4 to 8
hours. Skin patch: Up to 24 hours.
Oral forms used as a preventive should be taken
30 minutes before or 1 to 2 hours after meals.
Store in a tightly sealed container away from
heat, moisture, and direct light.
If You Miss a Dose
Take it as soon as you remember. If it is near
the time for the next dose, skip the missed dose and resume
your regular dosage schedule, as prescribed. Do not double
the next dose.
Stopping the Drug
The decision to stop taking nitroglycerin should
be made by your doctor.
You should see your doctor regularly for examinations
and tests if you take this medicine for a prolonged period.
Over 60: Adverse
reactions may be more likely and more severe in older patients.
Driving and Hazardous Work: Do
not drive or engage in hazardous work until you determine how
the medicine affects you.
Alcohol: Avoid alcohol.
Pregnancy: Not recommended
during pregnancy. Before taking nitroglycerin, be sure to tell
your doctor if you are pregnant or plan to become pregnant.
Breast Feeding: Nitroglycerin
may pass into breast milk; caution is advised. Consult your
doctor for advice.
Infants and Children: No
studies in infants and children have been done.
Special Concerns: Skin
patch should be applied to different sites to prevent skin
Symptoms: Fast heartbeat,
red and perspiring skin, headache, dizziness, palpitations,
vision disturbances, nausea, vomiting, confusion, difficulty
What to Do: Call
your doctor, emergency medical services (EMS), or the nearest
poison control center immediately.
Do not take nitroglycerin within 24 hours of
taking sildenafil citrate. Sildenafil can enhance the action
of nitrates (such as nitroglycerin), causing potentially dangerous
decreases in blood pressure.
Consult your doctor for specific advice if you
are taking other heart medicines or drugs for hypertension.
No known food interactions.
Consult your physician if you have any of the
following: anemia, glaucoma, a recent head injury or stroke,
a recent heart attack, or an overactive thyroid. Use of nitroglycerin
may cause complications in patients with severe liver or kidney
disease, since these organs work together to remove the medication
from the body.
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