Brand Name: Celebrex
Drug Class: Nonsteroidal
anti-inflammatory drug (NSAID)/COX-2 inhibitor
Available in: Capsules
Available OTC? No
As Generic? No
ulcers. Black, tarry stools may signal stomach bleeding. Symptoms
of liver disease (nausea, fatigue, lethargy, itching, yellowish discoloration
of the eyes or skin, fluid retention). Call your doctor immediately.
diarrhea, and mild abdominal pain.
Less Common: Flatulence,
mild swelling, sore throat, and upper respiratory tract infection.
To relieve the pain, inflammation, and stiffness
of osteoarthritis and rheumatoid arthritis.
How the Drug Works
By inhibiting the activity of the enzyme cyclooxygenase-2
(COX-2), celecoxib reduces the synthesis of prostaglandins that
play a role in causing arthritis pain and inflammation. It does
not inhibit the activity of COX-1, the enzyme involved in the
synthesis of prostaglandins that help protect against stomach
ulcers and other health problems.
For osteoarthritis: 200 mg a day, either
as one single dose or 100 mg twice a day. For rheumatoid arthritis: 100
to 200 mg twice a day. To minimize potential gastrointestinal
side effects, the lowest effective dose should be used for the
shortest possible time.
Onset of Effect
Within 24 to 48 hours.
Duration of Action
Celecoxib may be taken with or without food.
Store in a tightly sealed container away from heat,
moisture, and direct light.
If You Miss a Dose
Take it as soon as you remember. If it is near
the time for the next dose, skip the missed dose and resume your
regular dosage schedule. Do not double the next dose.
Stopping the Drug
The decision to stop taking the drug should be
made in consultation with your physician.
The risk of gastrointestinal side effects may be
increased with extended use.
Over 60: Adverse
reactions may be more likely and more severe in older patients.
Driving and Hazardous Work: No
special problems are expected.
Alcohol: Avoid alcohol
when using this medication because it increases the risk of
with your doctor the relative risks and benefits of using this
drug while pregnant. Do not use celecoxib during the last trimester.
Breast Feeding: Celecoxib
may pass into breast milk; caution is advised. Consult your
doctor for advice on whether to discontinue nursing or discontinue
Infants and Children: The
safety and effectiveness of this drug have not been established
for children under the age of 18.
Symptoms: No cases
of overdose have been reported. Symptoms may include lethargy,
drowsiness, nausea, vomiting, abdominal pain, black, tarry
stools, breathing difficulty, and coma.
What to Do: If you
suspect an overdose or if someone takes a much larger dose
than prescribed, call your doctor, emergency medical services
(EMS), or the nearest poison control center immediately.
Do not take this drug with aspirin or any other
NSAIDs without your doctors approval. In addition, consult
your doctor if you are taking furosemide, ACE inhibitors, fluconazole,
lithium, or warfarin.
No known food interactions.
Celecoxib should not be taken by people who have
experienced asthma, hives, or allergic-type reactions after taking
aspirin or other NSAIDs. Consult your doctor if you have any
of the following: bleeding problems, inflammation or ulcers of
the stomach and intestines, asthma, high blood pressure, or heart
failure. Use of celecoxib may cause complications in patients
with liver or kidney disease, since these organs work together
to remove the medication from the body.
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